Hormone & Growth Signaling
Peptides in this category interact with endocrine signaling systems that regulate growth, repair, metabolism, and tissue adaptation. Many function by influencing growth hormone pathways, insulin-like growth factors, or upstream hypothalamic signaling that coordinates systemic anabolic and recovery responses. These compounds are typically discussed in contexts involving recovery capacity, tissue regeneration signaling, metabolic regulation, and adaptive physiological responses to stress, training, and energy balance.
CJC-1295 DAC
Early human dataCJC-1295 with DAC is an albumin-binding, long-acting GHRH analogue that raised GH and IGF-I for days in small 2006 trials in healthy adults. No outcome data; not approved.
human 2 · sources 5
CJC-1295 no DAC
No human dataCJC-1295 no DAC (modified GRF 1-29) is the tetrasubstituted GHRH(1-29) fragment without the albumin-binding group. The cited human trials used the DAC form; none tested this one.
human 2 · sources 5
IGF-1 LR3
No human dataAn engineered IGF-1 analogue designed to evade IGF binding proteins. Never tested in people; the human data nearby concerns natural IGF-I and cancer risk, and the approved unmodified hormone.
human 2 · sources 7
Ipamorelin
Early human dataIpamorelin is a synthetic ghrelin-receptor peptide that releases growth hormone. Its human data are one volunteer pharmacology study and one Phase 2 bowel surgery trial that did not beat placebo.
human 2 · sources 5
MK-677
Controlled human trialsAn orally active non-peptide ghrelin mimetic that reliably raises growth hormone and IGF-1. In placebo-controlled trials it added fat-free mass in healthy older adults without improving strength or function.
human 4 · sources 7
Sermorelin
Controlled human trialsSermorelin is GHRH(1-29), approved as Geref until 2009 for growth failure in growth-hormone-deficient children and for pituitary testing, with randomised paediatric trials and no controlled adult outcome data.
human 12 · sources 18